Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.

Yan, Bo; Ai, Youwei; Sun, Qi; Ma, Yan; Cao, Yang; Wang, Jiawen; Zhang, Zhiyuan; Wang, Xiaodong

Yan, Bo; Ai, Youwei; Sun, Qi; Ma, Yan; Cao, Yang; Wang, Jiawen; Zhang, Zhiyuan; Wang, Xiaodong.

Afiliação

Yan B; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China. Electronic address: yanbo@nibs.ac.cn.
Ai Y; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China. Electronic address: aiyouwei@nibs.ac.cn.
Sun Q; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.
Ma Y; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Cao Y; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Wang J; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Zhang Z; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.
Wang X; National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100871, China.

Mol Cell ; 81(2): 355-369.e10, 2021 01 21.

Article em En | MEDLINE | ID: mdl-33321093

Assuntos

Membrana Celular/química; Sistema Enzimático do Citocromo P-450/genética; Citocromo-B(5) Redutase/genética; Ácidos Graxos Insaturados/metabolismo; Ferroptose/genética; NADP/metabolismo; Animais; Linhagem Celular Tumoral; Membrana Celular/efeitos dos fármacos; Membrana Celular/metabolismo; Concanavalina A/farmacologia; Sistema Enzimático do Citocromo P-450/deficiência; Citocromo-B(5) Redutase/deficiência; Transporte de Elétrons/efeitos dos fármacos; Ferroptose/efeitos dos fármacos; Células HEK293; Células HeLa; Humanos; Peróxido de Hidrogênio/metabolismo; Peroxidação de Lipídeos/efeitos dos fármacos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Nus; Oxigênio/metabolismo; Compostos de Fenilureia/farmacologia; Piperazinas/farmacologia; Piridinas/farmacologia; Sorafenibe/farmacologia

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Membrana Celular / Sistema Enzimático do Citocromo P-450 / Citocromo-B(5) Redutase / Ácidos Graxos Insaturados / Ferroptose / NADP Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article

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