Big-Data Glycomics: Tools to Connect Glycan Biosynthesis to Extracellular Communication.
Trends Biochem Sci
; 46(4): 284-300, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33349503
ABSTRACT
Characteristically, cells must sense and respond to environmental cues. Despite the importance of cell-cell communication, our understanding remains limited and often lacks glycans. Glycans decorate proteins and cell membranes at the cell-environment interface, and modulate intercellular communication, from development to pathogenesis. Providing further challenges, glycan biosynthesis and cellular behavior are co-regulating systems. Here, we discuss how glycosylation contributes to extracellular responses and signaling. We further organize approaches for disentangling the roles of glycans in multicellular interactions using newly available datasets and tools, including glycan biosynthesis models, omics datasets, and systems-level analyses. Thus, emerging tools in big data analytics and systems biology are facilitating novel insights on glycans and their relationship with multicellular behavior.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Glicômica
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos