Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling.

Zheng, Yi; Zhuang, Meng-Wei; Han, Lulu; Zhang, Jing; Nan, Mei-Ling; Zhan, Peng; Kang, Dongwei; Liu, Xinyong; Gao, Chengjiang; Wang, Pei-Hui

Zheng, Yi; Zhuang, Meng-Wei; Han, Lulu; Zhang, Jing; Nan, Mei-Ling; Zhan, Peng; Kang, Dongwei; Liu, Xinyong; Gao, Chengjiang; Wang, Pei-Hui.

Afiliação

Zheng Y; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhuang MW; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Han L; Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhang J; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Nan ML; Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China.
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Kang D; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Gao C; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Wang PH; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.

Signal Transduct Target Ther ; 5(1): 299, 2020 12 28.

Article em En | MEDLINE | ID: mdl-33372174

Assuntos

COVID-19/metabolismo; Proteína DEAD-box 58/metabolismo; Interferon Tipo I/biossíntese; Helicase IFIH1 Induzida por Interferon/metabolismo; Interferons/biossíntese; SARS-CoV-2/metabolismo; Transdução de Sinais; Proteínas da Matriz Viral/metabolismo; Animais; COVID-19/genética; Chlorocebus aethiops; Proteína DEAD-box 58/genética; Células HEK293; Células HeLa; Humanos; Interferon Tipo I/genética; Helicase IFIH1 Induzida por Interferon/genética; Interferons/genética; Receptores Imunológicos; SARS-CoV-2/genética; Células Vero; Proteínas da Matriz Viral/genética; Interferon lambda

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Transdução de Sinais / Interferon Tipo I / Proteínas da Matriz Viral / Interferons / Proteína DEAD-box 58 / Helicase IFIH1 Induzida por Interferon / SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Signal Transduct Target Ther Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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