A deafness-associated tRNA mutation caused pleiotropic effects on the m1G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation.

Meng, Feilong; Zhou, Mi; Xiao, Yun; Mao, Xiaoting; Zheng, Jing; Lin, Jiaxi; Lin, Tianxiang; Ye, Zhenzhen; Cang, Xiaohui; Fu, Yong; Wang, Meng; Guan, Min-Xin

Meng, Feilong; Zhou, Mi; Xiao, Yun; Mao, Xiaoting; Zheng, Jing; Lin, Jiaxi; Lin, Tianxiang; Ye, Zhenzhen; Cang, Xiaohui; Fu, Yong; Wang, Meng; Guan, Min-Xin.

Afiliação

Meng F; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou, Zhejiang 310058, China.
Zhou M; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Xiao Y; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Mao X; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Zheng J; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Lin J; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou, Zhejiang 310058, China.
Lin T; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Ye Z; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Cang X; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Fu Y; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou, Zhejiang 310058, China.
Wang M; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Guan MX; Division of Otolaryngology-Head and Neck Surgery, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

Nucleic Acids Res ; 49(2): 1075-1093, 2021 01 25.

Article em En | MEDLINE | ID: mdl-33398350

Assuntos

Perda Auditiva Neurossensorial/genética; Mutação Puntual; RNA de Transferência de Isoleucina/genética; Trifosfato de Adenosina/biossíntese; Adulto; Proteínas Arqueais/metabolismo; Autofagia; Sequência de Bases; Linhagem Celular; DNA Mitocondrial/genética; Etnicidade/genética; Feminino; Pleiotropia Genética; Perda Auditiva Neurossensorial/etnologia; Humanos; Isoleucina/metabolismo; Masculino; Herança Materna; Potencial da Membrana Mitocondrial; Methanocaldococcus/enzimologia; Metilação; Pessoa de Meia-Idade; Mitocôndrias/metabolismo; Simulação de Dinâmica Molecular; Conformação de Ácido Nucleico; Fosforilação Oxidativa; Linhagem; Biossíntese de Proteínas; Processamento Pós-Transcricional do RNA; Proteínas Recombinantes/metabolismo; Aminoacilação de RNA de Transferência; Adulto Jovem; tRNA Metiltransferases/metabolismo

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: RNA de Transferência de Isoleucina / Mutação Puntual / Perda Auditiva Neurossensorial Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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