Liver injury after antiviral treatment of critically ill patients with COVID-19: a single-centered retrospective cohort study.
Ann Palliat Med
; 10(3): 2429-2438, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33440980
ABSTRACT
BACKGROUND:
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the causative agent of coronavirus disease 2019 (COVID-19). Lung lesions are considered to be the main damage caused by SARSCoV-2 infection. In addition, liver injury has also been reported to occur during the course of the disease in severe cases. However, the effect of antiviral treatment on liver injury in critically ill patients is not yet clear.METHODS:
We retrospectively evaluated the effect of antiviral treatment and antiviral drug arbidol on liver injury in COVID-19 critically ill patients. Baseline characteristics were collected from patients who were admitted to intensive care units of Tongji Hospital in Wuhan, China, and confounders were balanced by propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) analyses.RESULTS:
Both the PSM (OR=2.77; 95% CI 1.03, 7.48; P=0.045) and the IPTW-adjusted (OR=2.33; 95% CI 1.02, 5.34; P=0.047) results showed that COVID-19 critically ill patients receiving antiviral treatment had a significantly higher risk of liver injury. However, arbidol treatment did not have a significant effect on liver injury (IPTW OR=2.11; 95% CI 0.79, 5.67; P=0.14).CONCLUSIONS:
Our results show that although arbidol treatment does not seem to be significantly associated with liver injury complications, the overall use of antiviral drugs increases the risk of liver injury for critically ill patients with COVID-19. Antiviral drugs are widely used to treat COVID-19, but we recommend that for critically ill patients, antiviral treatment should be used with caution considering both effectiveness and potential adverse effects.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Antivirais
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Tratamento Farmacológico da COVID-19
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Indóis
/
Fígado
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Ann Palliat Med
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China