Reversible (Patho)Physiologically Relevant Test Interventions: Rationale and Examples.
Methods Mol Biol
; 2216: 57-73, 2021.
Article
em En
| MEDLINE
| ID: mdl-33475994
ABSTRACT
Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe test interventions that are used to study the control of renal hemodynamics and oxygenation in experimental animals in the context of kidney-specific control of hemodynamics and oxygenation. The rationale behind the use of the individual tests, the physiological responses of renal hemodynamics and oxygenation, the use in preclinical studies, and the possible application in humans are discussed.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Oxigênio
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Circulação Renal
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Processamento de Imagem Assistida por Computador
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Imageamento por Ressonância Magnética
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Biomarcadores
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Rim
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Monitorização Fisiológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha