The prion protein is not required for peripheral nerve de- and remyelination after crush injury.
PLoS One
; 16(1): e0245944, 2021.
Article
em En
| MEDLINE
| ID: mdl-33481951
ABSTRACT
The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peripheral nerves. PrP activates the adhesion G-protein coupled receptor Adgrg6 on Schwann cells and initiates a pro-myelination cascade of molecular signals. Because Adgrg6 is crucial for peripheral myelin development and regeneration after nerve injury, we investigated the role of PrP in peripheral nerve repair. We performed experimental sciatic nerve crush injuries in co-isogenic wild-type and PrP-deficient mice, and examined peripheral nerve repair processes. Generation of repair Schwann cells, macrophage recruitment and remyelination were similar in PrP-deficient and wild-type mice. We conclude that PrP is dispensable for sciatic nerve de- and remyelination after crush injury. Adgrg6 may sustain its function in peripheral nerve repair independently of its activation by PrP.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Células de Schwann
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Nervo Isquiático
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Receptores Acoplados a Proteínas G
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Traumatismos dos Nervos Periféricos
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Proteínas Priônicas
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Remielinização
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Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Suíça