Reciprocal communication of pericoronary adipose tissue and coronary atherogenesis.
Eur J Radiol
; 136: 109531, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33486436
ABSTRACT
OBJECTIVE:
Pericoronary adipose tissue (PCAT) has been linked to underlying coronary artery disease (CAD) and proposed to modulate adjacent atherosclerotic plaque formation over pro-inflammatory pathways. In vitro and ex vivo studies support the bilateral communication of adipose tissue and vessel wall. We quantified PCAT and its dynamics in a low coronary risk cohort with a semi-automated software in serial coronary computed tomography angiography (CTA).METHODS:
We retrospectively included patients from a tertiary care hospital who underwent serial coronary CTA with a low cardiovascular risk profile. All examinations were evaluated in a standardizedapproach:
epicardial adipose tissue (EAT) volume and attenuation was quantified in total, in the atrioventricular (RCA, LCX) or interventricular (LAD) sulcus and within a 5â¯mm radius for each coronary artery (PCAT). Coronary plaques were quantified using a semi-automated software and compared for progression, stability or regression.RESULTS:
Of 120 patients (27% females), 59.2% showed atherosclerotic plaques. After 36 months mean follow-up, 22 (18.3%) showed plaque regression, 39 (32.5%) were stable and 49 (40.8%) were progressive. Total EAT volume decreased by -15.6⯱â¯37.2â¯mm³ in the regressive group, increased by 2.7⯱â¯30.6â¯mm³ in the stable group and by 24.3⯱â¯37.1â¯mm³ in the progressive group (pâ¯=â¯0.003). Per-vessel analysis showed a significant decrease of PCAT attenuation in patients with CAD regression (-3.8⯱â¯7.6HU) compared to the stable (1.2⯱â¯9.1HU) and progressive group (3.5⯱â¯8.2HU, pâ¯<â¯0.0001). Mean sulcus EAT attenuation did not show a significant change (pâ¯=â¯0.135).CONCLUSION:
Epicardial adipose tissue volume is mutually changing with the progression or regression of coronary artery disease. Perivascular but not epicardial attenuation levels correlate to adjacent plaque and support a direct bilateral influence.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Aterosclerose
/
Placa Aterosclerótica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Radiol
Ano de publicação:
2021
Tipo de documento:
Article