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Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds.
Rucins, Martins; Smits, Rufus; Sipola, Anda; Vigante, Brigita; Domracheva, Ilona; Turovska, Baiba; Muhamadejev, Ruslan; Pajuste, Karlis; Plotniece, Mara; Sobolev, Arkadij; Duburs, Gunars; Plotniece, Aiva.
Afiliação
  • Rucins M; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Smits R; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Sipola A; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Vigante B; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Domracheva I; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Turovska B; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Muhamadejev R; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Pajuste K; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Plotniece M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Riga Stradins University, Dzirciema 16, Riga LV-1007, Latvia.
  • Sobolev A; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Duburs G; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
  • Plotniece A; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia.
Oxid Med Cell Longev ; 2020: 8413713, 2020.
Article em En | MEDLINE | ID: mdl-33488932
ABSTRACT
Three groups of synthetic lipids are chosen for studies (1) 1,4-dihydropyridines (1,4-DHPs) containing two cationic moieties and their analogues; (2) 3,4-dihydro-2(1H)-pyridones containing a cationic moiety; and (3) acyclic, open-chain analogues, i.e., 2-amino-3-alkoxycarbonylalkylammonium derivatives. 1,4-DHPs possessing dodecyl alkyl chains in the ester groups in positions 3 and 5 and cationic nitrogen-containing groups in positions 2 and 6 have high cytotoxicity in cancer cells HT-1080 (human lung fibrosarcoma) and MH-22A (mouse hepatoma), but low cytotoxicity in the noncancerous NIH3T3 cells (mouse embryonic fibroblast). On the contrary, similar compounds having short (methyl, ethyl, or propoxyethyl) chains in the ester groups in positions 3 and 5 lack cytotoxicity in the cancer cells HT-1080 and MH-22A even at high doses. Inclusion of fluorine atoms in the alkyl chains in positions 3 and 5 of the DHP cycle decreases the cytotoxicity of the mentioned compounds. Structurally related dihydropyridones with a polar head group are substantially more toxic to normal and cancerous cells than the DHP analogues. Open-chain analogues of DHP lipids comprise the same conjugated aminovinylcarbonyl moiety and possess anticancer activity, but they also have high basal cytotoxicity. Electrochemical oxidation data demonstrate that oxidation potentials of selected compounds are in the range of 1.6-1.7 V for cationic 1,4-DHP, 2.0-2.4 V for cationic 3,4-dihydropyridones, and 1.2-1.5 V for 2-amino-3-alkoxycarbonylalkylammonium derivatives. Furthermore, the tested cationic 1,4-DHP amphiphiles possess antiradical activity. Molecular topological polar surface area values for the tested compounds were defined in accordance with the main fragments of compound structures. The determined logP values were highest for dodecyl ester groups in positions 3 and 5 of the 1,4-DHP and lowest for short alkyl chain-containing amphiphiles.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piridonas / Compostos de Vinila / Di-Hidropiridinas / Carcinoma Hepatocelular / Proliferação de Células / Fibrossarcoma / Pneumopatias Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Letônia

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piridonas / Compostos de Vinila / Di-Hidropiridinas / Carcinoma Hepatocelular / Proliferação de Células / Fibrossarcoma / Pneumopatias Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Letônia