Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins.

Wei, Tongyao; Liu, Heng; Chu, Bizhu; Blasco, Pilar; Liu, Zheng; Tian, Ruijun; Li, David Xiang; Li, Xuechen

Wei, Tongyao; Liu, Heng; Chu, Bizhu; Blasco, Pilar; Liu, Zheng; Tian, Ruijun; Li, David Xiang; Li, Xuechen.

Afiliação

Wei T; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China.
Liu H; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China.
Chu B; Department of Chemistry, Southern University of Science and Technology, Shenzhen, P. R. China.
Blasco P; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China.
Liu Z; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China.
Tian R; Department of Chemistry, Southern University of Science and Technology, Shenzhen, P. R. China.
Li DX; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China.
Li X; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China. Electronic address: xuechenl@hku.hk.

Cell Chem Biol ; 28(5): 722-732.e8, 2021 05 20.

Article em En | MEDLINE | ID: mdl-33545070

Assuntos

Proteína HMGA1a/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Feminino; Células HEK293; Proteína HMGA1a/química; Proteína HMGA1a/isolamento & purificação; Humanos; Espectrometria de Massas; Fosforilação; Ligação Proteica; Processamento de Proteína Pós-Traducional; Proteína Supressora de Tumor p53/química; Proteína Supressora de Tumor p53/isolamento & purificação

Palavras-chave

HMGA; P53; chemical protein synthesis; conformational change; intrinsically disordered protein; protein phosphorylation

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Proteína HMGA1a Limite: Female / Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2021 Tipo de documento: Article

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