In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump.

Odiase, Eunice; Zhang, Xi; Chang, Yan; Nelson, Melissa; Balaji, Uthra; Gu, Jinghua; Zhang, Qiuyang; Pan, Zui; Spechler, Stuart Jon; Souza, Rhonda F

Odiase, Eunice; Zhang, Xi; Chang, Yan; Nelson, Melissa; Balaji, Uthra; Gu, Jinghua; Zhang, Qiuyang; Pan, Zui; Spechler, Stuart Jon; Souza, Rhonda F.

Afiliação

Odiase E; Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas; Department of Pediatrics, Children's Hospital of Colorado, Aurora, Colorado.
Zhang X; Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas.
Chang Y; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
Nelson M; Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas.
Balaji U; Biostatistics Core, Baylor Scott & White Research Institute, Dallas, Texas.
Gu J; Biostatistics Core, Baylor Scott & White Research Institute, Dallas, Texas.
Zhang Q; Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas.
Pan Z; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
Spechler SJ; Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas.
Souza RF; Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas. Electronic address: rhonda.souza@BSWHealth.org.

Gastroenterology ; 160(6): 2072-2088.e6, 2021 05.

Article em En | MEDLINE | ID: mdl-33581123

Assuntos

Quimiocina CCL26/metabolismo; Esofagite Eosinofílica/metabolismo; Esofagite Eosinofílica/patologia; Células Epiteliais/metabolismo; ATPase Trocadora de Hidrogênio-Potássio/genética; ATPase Trocadora de Hidrogênio-Potássio/metabolismo; Transporte Biológico/efeitos dos fármacos; Compostos de Boro/farmacologia; Cálcio/metabolismo; Bloqueadores dos Canais de Cálcio/farmacologia; Linhagem Celular; Diltiazem/farmacologia; Ácido Egtázico/análogos & derivados; Ácido Egtázico/farmacologia; Mucosa Esofágica/metabolismo; Mucosa Esofágica/patologia; Famotidina/farmacologia; Feminino; Antagonistas dos Receptores H2 da Histamina/farmacologia; Humanos; Subunidade alfa de Receptor de Interleucina-4/metabolismo; Masculino; Omeprazol/farmacologia; Cultura Primária de Células; Inibidores da Bomba de Prótons/farmacologia; Bombas de Próton/efeitos dos fármacos; Bombas de Próton/metabolismo; RNA Mensageiro/metabolismo; Ranitidina/farmacologia; Transdução de Sinais/efeitos dos fármacos; Células Th2/metabolismo; Verapamil/farmacologia

Palavras-chave

Diltiazem; Potassium-Competitive Acid Blockers; Proton Pump Inhibitors; Verapamil

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: ATPase Trocadora de Hidrogênio-Potássio / Células Epiteliais / Esofagite Eosinofílica / Quimiocina CCL26 Limite: Female / Humans / Male Idioma: En Revista: Gastroenterology Ano de publicação: 2021 Tipo de documento: Article

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