Does Intravenous Thrombolysis Within 4.5 to 9 Hours Increase Clot Migration Leading to Endovascular Inaccessibility?
Stroke
; 52(3): 1083-1086, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33588590
ABSTRACT
BACKGROUND AND PURPOSE:
Distal clot migration is a recognized event following intravenous thrombolysis (IVT) in the setting of acute ischemic stroke. Of note, clots that were initially retrievable by endovascular thrombectomy may migrate to a distal nonretrievable location and compromise clinical outcome. We investigated the incidence of clot migration leading to clot inaccessibility following IVT in the time window of 4.5 to 9 hours.METHODS:
We performed a retrospective analysis of the EXTEND trial (Extending the Time for Thrombolysis in Emergency Neurological Deficits) data. Baseline and 12- to 24-hour follow-up clot location was determined on computed tomography angiogram or magnetic resonance angiogram. The incidence of clot migration leading to a change from retrievable to nonretrievable location was identified and compared between the two treatment groups (IVT versus placebo).RESULTS:
Two hundred twenty patients were assessed. Clot migration from a retrievable to nonretrievable location occurred in 37 patients 21 patients (19.3%) in the placebo group and 16 patients (14.4%) in the IVT group. No significant difference was identified in the incidence of clot migration leading to inaccessibility between groups (P=0.336).CONCLUSIONS:
Our results did not show increased clot migration leading to clot inaccessibility in patients treated with IVT.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Terapia Trombolítica
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Procedimentos Endovasculares
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Fibrinolíticos
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AVC Isquêmico
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Stroke
Ano de publicação:
2021
Tipo de documento:
Article