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Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.
Horowitz, J E; Kosmicki, J A; Damask, A; Sharma, D; Roberts, G H L; Justice, A E; Banerjee, N; Coignet, M V; Yadav, A; Leader, J B; Marcketta, A; Park, D S; Lanche, R; Maxwell, E; Knight, S C; Bai, X; Guturu, H; Sun, D; Baltzell, A; Kury, F S P; Backman, J D; Girshick, A R; O'Dushlaine, C; McCurdy, S R; Partha, R; Mansfield, A J; Turissini, D A; Li, A H; Zhang, M; Mbatchou, J; Watanabe, K; Gurski, L; McCarthy, S E; Kang, H M; Dobbyn, L; Stahl, E; Verma, A; Sirugo, G; Ritchie, M D; Jones, M; Balasubramanian, S; Siminovitch, K; Salerno, W J; Shuldiner, A R; Rader, D J; Mirshahi, T; Locke, A E; Marchini, J; Overton, J D; Carey, D J.
Afiliação
  • Horowitz JE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Kosmicki JA; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Damask A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Sharma D; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Roberts GHL; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Justice AE; Geisinger, Danville, PA, 17822, USA.
  • Banerjee N; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Coignet MV; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Yadav A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Leader JB; Geisinger, Danville, PA, 17822, USA.
  • Marcketta A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Park DS; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Lanche R; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Maxwell E; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Knight SC; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Bai X; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Guturu H; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Sun D; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Baltzell A; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Kury FSP; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Backman JD; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Girshick AR; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • O'Dushlaine C; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • McCurdy SR; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Partha R; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Mansfield AJ; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Turissini DA; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Li AH; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Zhang M; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
  • Mbatchou J; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Watanabe K; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Gurski L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • McCarthy SE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Kang HM; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Dobbyn L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Stahl E; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Sirugo G; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Jones M; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Balasubramanian S; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Siminovitch K; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Salerno WJ; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Shuldiner AR; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Mirshahi T; Geisinger, Danville, PA, 17822, USA.
  • Locke AE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Marchini J; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Overton JD; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
  • Carey DJ; Geisinger, Danville, PA, 17822, USA.
medRxiv ; 2021 Jun 10.
Article em En | MEDLINE | ID: mdl-33619501
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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: MedRxiv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: MedRxiv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos