Consensus guidelines for botulinum toxin therapy: general algorithms and dosing tables for dystonia and spasticity.
J Neural Transm (Vienna)
; 128(3): 321-335, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33635442
ABSTRACT
Botulinum toxin (BT) therapy is a complex and highly individualised therapy defined by treatment algorithms and injection schemes describing its target muscles and their dosing. Various consensus guidelines have tried to standardise and to improve BT therapy. We wanted to update and improve consensus guidelines by (1) Acknowledging recent advances of treatment algorithms. (2) Basing dosing tables on statistical analyses of real-life treatment data of 1831 BT injections in 36 different target muscles in 420 dystonia patients and 1593 BT injections in 31 different target muscles in 240 spasticity patients. (3) Providing more detailed dosing data including typical doses, dose variabilities, and dosing limits. (4) Including total doses and target muscle selections for typical clinical entities thus adapting dosing to different aetiologies and pathophysiologies. (5) In addition, providing a brief and concise review of the clinical entity treated together with general principles of its BT therapy. For this, we collaborated with IAB-Interdisciplinary Working Group for Movement Disorders which invited an international panel of experts for the support.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Toxinas Botulínicas
/
Toxinas Botulínicas Tipo A
/
Distúrbios Distônicos
/
Distonia
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
J Neural Transm (Vienna)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha