Your browser doesn't support javascript.
loading
Rationale and design of the Kidney Precision Medicine Project.
de Boer, Ian H; Alpers, Charles E; Azeloglu, Evren U; Balis, Ulysses G J; Barasch, Jonathan M; Barisoni, Laura; Blank, Kristina N; Bomback, Andrew S; Brown, Keith; Dagher, Pierre C; Dighe, Ashveena L; Eadon, Michael T; El-Achkar, Tarek M; Gaut, Joseph P; Hacohen, Nir; He, Yongqun; Hodgin, Jeffrey B; Jain, Sanjay; Kellum, John A; Kiryluk, Krzysztof; Knight, Richard; Laszik, Zoltan G; Lienczewski, Chrysta; Mariani, Laura H; McClelland, Robyn L; Menez, Steven; Moledina, Dennis G; Mooney, Sean D; O'Toole, John F; Palevsky, Paul M; Parikh, Chirag R; Poggio, Emilio D; Rosas, Sylvia E; Rosengart, Matthew R; Sarwal, Minnie M; Schaub, Jennifer A; Sedor, John R; Sharma, Kumar; Steck, Becky; Toto, Robert D; Troyanskaya, Olga G; Tuttle, Katherine R; Vazquez, Miguel A; Waikar, Sushrut S; Williams, Kayleen; Wilson, Francis Perry; Zhang, Kun; Iyengar, Ravi; Kretzler, Matthias; Himmelfarb, Jonathan.
Afiliação
  • de Boer IH; Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address: deboer@u.washington.edu.
  • Alpers CE; Department of Pathology, University of Washington, Seattle, Washington, USA.
  • Azeloglu EU; Department of Medicine, Icahn School of Medicine at Mt. Sinai, New York, New York, USA.
  • Balis UGJ; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
  • Barasch JM; Department of Pathology, Columbia University, New York, New York, USA.
  • Barisoni L; Department of Pathology, Duke University, Durham, North Carolina, USA.
  • Blank KN; Department of Biostatistics, University of Washington, Seattle, Washington, USA.
  • Bomback AS; Department of Medicine, Columbia University, New York, New York, USA.
  • Brown K; Patient Representative, Kidney Precision Medicine Project Steering Committee Member.
  • Dagher PC; Department of Medicine, Indiana University, Indianapolis, Indiana, USA.
  • Dighe AL; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Eadon MT; Department of Medicine, Indiana University, Indianapolis, Indiana, USA.
  • El-Achkar TM; Department of Medicine, Indiana University, Indianapolis, Indiana, USA.
  • Gaut JP; Department of Pathology, Washington University School of Medicine, St. Louis, St. Louis, Missouri, USA.
  • Hacohen N; Broad Institute, Cambridge, Massachusetts, USA.
  • He Y; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
  • Hodgin JB; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
  • Jain S; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, Missouri, USA.
  • Kellum JA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Kiryluk K; Department of Medicine, Columbia University, New York, New York, USA.
  • Knight R; American Association of Kidney Patients, Kidney Precision Medicine Project Patient Partner.
  • Laszik ZG; Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
  • Lienczewski C; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Mariani LH; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • McClelland RL; Department of Biostatistics, University of Washington, Seattle, Washington, USA.
  • Menez S; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Moledina DG; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
  • Mooney SD; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA.
  • O'Toole JF; Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.
  • Palevsky PM; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Renal Section, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
  • Parikh CR; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Poggio ED; Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.
  • Rosas SE; Joslin Diabetes Center, Boston, Massachusetts, USA.
  • Rosengart MR; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Sarwal MM; Department of Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Schaub JA; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Sedor JR; Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.
  • Sharma K; Department of Medicine, UT Health San Antonio, San Antonio, Texas, USA.
  • Steck B; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Toto RD; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
  • Troyanskaya OG; Department of Computer Science, Princeton University, Princeton, New Jersey, USA.
  • Tuttle KR; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Vazquez MA; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
  • Waikar SS; Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA.
  • Williams K; Department of Biostatistics, University of Washington, Seattle, Washington, USA.
  • Wilson FP; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
  • Zhang K; Institute for Genomic Sciences, University of California, San Diego, California, USA.
  • Iyengar R; Mount Sinai Institute for Systems Biomedicine, Mount Sinai, New York, New York, USA.
  • Kretzler M; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Himmelfarb J; Department of Medicine, University of Washington, Seattle, Washington, USA.
Kidney Int ; 99(3): 498-510, 2021 03.
Article em En | MEDLINE | ID: mdl-33637194
ABSTRACT
Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Injúria Renal Aguda Tipo de estudo: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Kidney Int Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Injúria Renal Aguda Tipo de estudo: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Kidney Int Ano de publicação: 2021 Tipo de documento: Article