An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential GSK3ß/ß-Catenin/STAT3/CD44 Suppressor with Anti-Glioblastoma Properties.

Mokgautsi, Ntlotlang; Wen, Ya-Ting; Lawal, Bashir; Khedkar, Harshita; Sumitra, Maryam Rachmawati; Wu, Alexander T H; Huang, Hsu-Shan

An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential GSK3ß/ß-Catenin/STAT3/CD44 Suppressor with Anti-Glioblastoma Properties.

Mokgautsi, Ntlotlang; Wen, Ya-Ting; Lawal, Bashir; Khedkar, Harshita; Sumitra, Maryam Rachmawati; Wu, Alexander T H; Huang, Hsu-Shan.

Afiliação

Mokgautsi N; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
Wen YT; Graduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Lawal B; Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei 11031, Taiwan.
Khedkar H; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
Sumitra MR; Graduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Wu ATH; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
Huang HS; Graduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

Int J Mol Sci ; 22(5)2021 Feb 28.

Article em En | MEDLINE | ID: mdl-33671112

Assuntos

Biologia Computacional/métodos; Glioblastoma/tratamento farmacológico; Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores; Receptores de Hialuronatos/antagonistas & inibidores; Niclosamida/química; Fator de Transcrição STAT3/antagonistas & inibidores; beta Catenina/antagonistas & inibidores; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/patologia; Diferenciação Celular; Proliferação de Células; Regulação Neoplásica da Expressão Gênica; Glioblastoma/metabolismo; Glioblastoma/patologia; Humanos; Simulação de Acoplamento Molecular; Células-Tronco Neoplásicas/efeitos dos fármacos; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Transdução de Sinais; Células Tumorais Cultivadas

Palavras-chave

drug resistance; glioblastoma multiforme (GBM); glioma stem cell (GSC); in silico molecular docking; miR-135b; stemness; tumor microenvironment (TME)

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Glioblastoma / Receptores de Hialuronatos / Biologia Computacional / Fator de Transcrição STAT3 / Beta Catenina / Glicogênio Sintase Quinase 3 beta / Niclosamida Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Taiwan

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