The Power of Yeast in Modelling Human Nuclear Mutations Associated with Mitochondrial Diseases.
Genes (Basel)
; 12(2)2021 02 20.
Article
em En
| MEDLINE
| ID: mdl-33672627
ABSTRACT
The increasing application of next generation sequencing approaches to the analysis of human exome and whole genome data has enabled the identification of novel variants and new genes involved in mitochondrial diseases. The ability of surviving in the absence of oxidative phosphorylation (OXPHOS) and mitochondrial genome makes the yeast Saccharomyces cerevisiae an excellent model system for investigating the role of these new variants in mitochondrial-related conditions and dissecting the molecular mechanisms associated with these diseases. The aim of this review was to highlight the main advantages offered by this model for the study of mitochondrial diseases, from the validation and characterisation of novel mutations to the dissection of the role played by genes in mitochondrial functionality and the discovery of potential therapeutic molecules. The review also provides a summary of the main contributions to the understanding of mitochondrial diseases emerged from the study of this simple eukaryotic organism.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Leveduras
/
Predisposição Genética para Doença
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Doenças Mitocondriais
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Modelos Biológicos
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Mutação
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Genes (Basel)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Itália