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Plasma pooling in combination with amotosalen/UVA pathogen inactivation to increase standardisation and safety of therapeutic plasma units.
Bubinski, Michal; Gronowska, Agnieszka; Szykula, Pawel; Kluska, Kamila; Kuleta, Ilona; Ciesielska, Emilia; Picard-Maureau, Marcus; Lachert, Elzbieta.
Afiliação
  • Bubinski M; Regional Blood Transfusion Center, Lodz, Poland.
  • Gronowska A; Regional Blood Transfusion Center, Lodz, Poland.
  • Szykula P; Regional Blood Transfusion Center, Lodz, Poland.
  • Kluska K; Regional Blood Transfusion Center, Lodz, Poland.
  • Kuleta I; Medical Laboratory SYNEVO, Lodz, Poland.
  • Ciesielska E; Medical Laboratory SYNEVO, Lodz, Poland.
  • Picard-Maureau M; Cerus Europe B.V., Amersfoort, The Netherlands.
  • Lachert E; Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
Transfus Med ; 31(2): 136-141, 2021 Apr.
Article em En | MEDLINE | ID: mdl-33686720
OBJECTIVES: Assessment of the impact of pooling five single-donor plasma (SDP) units to obtain six pathogen-reduced therapeutic plasma (PTP) units on standardisation and the retention of labile coagulation factors. BACKGROUND: SDP shows a high inter-donor variability with potential implications for the clinical treatment outcome. Additionally, there is still an existing risk for window-period transmissions of blood borne pathogens including newly emerging pathogens. METHODS/MATERIALS: Five ABO-identical SDP units were pooled, treated with the INTERTCEPT™ Blood System (Cerus Corporation, U.S.A.) and split into six PTP units which were frozen and thawed after 30 days. The variability in volume, labile coagulation factor retention and activity was assessed. RESULTS: The variability of volumes between the PTP units was reduced by 46% compared to SDP units. The variability in coagulation factor content between the PTP units was reduced by 63% compared to SDP units. Moderate, but significant losses of coagulation factors (except for vWF) were observed in PTPs compared to SDPs. CONCLUSION: The pooling of five SDP units to obtain six PTP units significantly increases product standardisation with potential implications for safety, economics as well as transfusion-transmitted pathogen safety, making it an interesting alternative to quarantine SDP (qSDP) and pathogen-reduced SDP.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Plasma / Furocumarinas / Raios Ultravioleta / Preservação de Sangue / Fármacos Fotossensibilizantes Tipo de estudo: Evaluation_studies Limite: Humans Idioma: En Revista: Transfus Med Assunto da revista: HEMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Plasma / Furocumarinas / Raios Ultravioleta / Preservação de Sangue / Fármacos Fotossensibilizantes Tipo de estudo: Evaluation_studies Limite: Humans Idioma: En Revista: Transfus Med Assunto da revista: HEMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia