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Chitosan Oligosaccharide Lactate-Coated Ultrasmall Gadolinium Oxide Nanoparticles: Synthesis, In Vitro Cytotoxicity, and Relaxometric Properties.
Ahmad, Mohammad Yaseen; Ahmad, Md Wasi; Yue, Huan; Ho, Son Long; Cha, Hyunsil; Marasini, Shanti; Tegafaw, Tirusew; Liu, Shuwen; Ghazanfari, Adibehalsadat; Chae, Kwon-Seok; Chang, Yongmin; Lee, Gang Ho.
Afiliação
  • Ahmad MY; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Ahmad MW; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Yue H; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Ho SL; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Cha H; Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, South Korea.
  • Marasini S; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Tegafaw T; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Liu S; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Ghazanfari A; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
  • Chae KS; Department of Biology Education, Teachers' College, Kyungpook National University, Taegu 41566, South Korea.
  • Chang Y; Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, South Korea.
  • Lee GH; Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, South Korea.
J Nanosci Nanotechnol ; 21(8): 4145-4150, 2021 08 01.
Article em En | MEDLINE | ID: mdl-33714294
ABSTRACT
In this study, hydrophilic and biocompatible chitosan oligosaccharide lactate (COL)-coated ultra-small gadolinium oxide nanoparticles (NPs) were synthesized through a one-pot polyol method and characterized by various experimental techniques. The In Vitro cellular cytotoxicity assay indicated that the COL-coated gadolinium oxide NPs were non-toxic up to 500 µM Gd. In addition, their water proton spin relaxivities (i.e., r1 and r2) were estimated to be 13.0 and 27.0 s-1mM-1, respectively, which are higher than those of commercial magnetic resonance imaging (MRI) contrast agents. The application potential of the solution sample as a T1 MRI contrast agent was demonstrated In Vitro by measuring map images in which dose-dependent contrast enhancements were observed.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Quitosana / Nanopartículas Idioma: En Revista: J Nanosci Nanotechnol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Coréia do Sul
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Quitosana / Nanopartículas Idioma: En Revista: J Nanosci Nanotechnol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Coréia do Sul