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Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities.
Vohidov, Farrukh; Andersen, Jannik N; Economides, Kyriakos D; Shipitsin, Michail V; Burenkova, Olga; Ackley, James C; Vangamudi, Bhavatarini; Nguyen, Hung V-T; Gallagher, Nolan M; Shieh, Peyton; Golder, Matthew R; Liu, Jenny; Dahlberg, William K; Ehrlich, Deborah J C; Kim, Julie; Kristufek, Samantha L; Huh, Sung Jin; Neenan, Allison M; Baddour, Joelle; Paramasivan, Sattanathan; de Stanchina, Elisa; Kc, Gaurab; Turnquist, David J; Saucier-Sawyer, Jennifer K; Kopesky, Paul W; Brady, Samantha W; Jessel, Michael J; Reiter, Lawrence A; Chickering, Donald E; Johnson, Jeremiah A; Blume-Jensen, Peter.
Afiliação
  • Vohidov F; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Andersen JN; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Economides KD; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Shipitsin MV; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Burenkova O; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Ackley JC; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Vangamudi B; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Gallagher NM; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Shieh P; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Golder MR; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Liu J; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Dahlberg WK; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Ehrlich DJC; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Kim J; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Kristufek SL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Huh SJ; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Neenan AM; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Baddour J; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Paramasivan S; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • de Stanchina E; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Kc G; Memorial Sloan Kettering Cancer Center, 417 E 68th St, New York, New York 10065, United States.
  • Turnquist DJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Saucier-Sawyer JK; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Kopesky PW; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Brady SW; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Jessel MJ; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Reiter LA; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Chickering DE; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Johnson JA; XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Blume-Jensen P; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
J Am Chem Soc ; 143(12): 4714-4724, 2021 03 31.
Article em En | MEDLINE | ID: mdl-33739832
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pró-Fármacos / Desenho de Fármacos / Proteínas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pró-Fármacos / Desenho de Fármacos / Proteínas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos