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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.
Weber, Evan W; Parker, Kevin R; Sotillo, Elena; Lynn, Rachel C; Anbunathan, Hima; Lattin, John; Good, Zinaida; Belk, Julia A; Daniel, Bence; Klysz, Dorota; Malipatlolla, Meena; Xu, Peng; Bashti, Malek; Heitzeneder, Sabine; Labanieh, Louai; Vandris, Panayiotis; Majzner, Robbie G; Qi, Yanyan; Sandor, Katalin; Chen, Ling-Chun; Prabhu, Snehit; Gentles, Andrew J; Wandless, Thomas J; Satpathy, Ansuman T; Chang, Howard Y; Mackall, Crystal L.
Afiliação
  • Weber EW; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Parker KR; Department of Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Sotillo E; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Lynn RC; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Anbunathan H; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Lattin J; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Good Z; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Belk JA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.
  • Daniel B; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Klysz D; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
  • Malipatlolla M; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Xu P; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Bashti M; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Heitzeneder S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Labanieh L; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Vandris P; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Majzner RG; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Qi Y; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Sandor K; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Chen LC; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Prabhu S; Department of Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Gentles AJ; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Wandless TJ; Department of Chemical and Systems Biology, Stanford University, CA 94305, USA.
  • Satpathy AT; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Chang HY; Department of Biomedical Informatics Research, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Mackall CL; Department of Chemical and Systems Biology, Stanford University, CA 94305, USA.
Science ; 372(6537)2021 04 02.
Article em En | MEDLINE | ID: mdl-33795428

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T / Imunoterapia Adotiva / Epigênese Genética / Dasatinibe / Receptores de Antígenos Quiméricos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Science Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T / Imunoterapia Adotiva / Epigênese Genética / Dasatinibe / Receptores de Antígenos Quiméricos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Science Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos