Prognostic Value of Apparent Diffusion Coefficient in Oropharyngeal Carcinoma.
Clin Neuroradiol
; 31(4): 1037-1048, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-33877396
ABSTRACT
PURPOSE:
To investigate clinical and radiological factors predicting worse outcome after (chemo)radiotherapy ([C]RT) in oropharyngeal squamous cell carcinoma (OPSCC) with a focus on apparent diffusion coefficient (ADC).METHODS:
This retrospective study included 67 OPSCC patients, treated with (C)RT with curative intent and diagnosed during 2013-2017. Human papilloma virus (HPV) association was detected with p16 immunohistochemistry. Of all 67 tumors, 55 were p16 positive, 9 were p16 negative, and in 3 the p16 status was unknown. Median follow-up time was 38 months. We analyzed pretreatment magnetic resonance imaging (MRI) for factors predicting disease-free survival (DFS) and locoregional recurrence (LRR), including primary tumor volume and the largest metastasis. Crude and p16-adjusted hazard ratios were analyzed using Cox proportional hazards model. Interobserver agreement was evaluated.RESULTS:
Disease recurred in 13 (19.4%) patients. High ADC predicted poor DFS, but not when the analysis was adjusted for p16. A break in RT (hazard ratio, HRâ¯= 3.972, 95% confidence interval, CI 1.445-10.917, pâ¯= 0.007) and larger metastasis volume (HRâ¯= 1.041, 95% CI 1.007-1.077, pâ¯= 0.019) were associated with worse DFS. A primary tumor larger than 7â¯cm3 was associated with increased LRR rate (HRâ¯= 4.861, 1.042-22.667, pâ¯= 0.044). Among p16-positive tumors, mean ADC was lower in grade 3 tumors compared to lower grade tumors (0.736 vs. 0.883; pâ¯= 0.003).CONCLUSION:
Low tumor ADC seems to be related to p16 positivity and therefore should not be used independently to evaluate disease prognosis or to choose patients for treatment deintensification.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Infecções por Papillomavirus
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Clin Neuroradiol
Assunto da revista:
NEUROLOGIA
/
RADIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Finlândia