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Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients.
Nguyen, Thi H O; Koutsakos, Marios; van de Sandt, Carolien E; Crawford, Jeremy Chase; Loh, Liyen; Sant, Sneha; Grzelak, Ludivine; Allen, Emma K; Brahm, Tim; Clemens, E Bridie; Auladell, Maria; Hensen, Luca; Wang, Zhongfang; Nüssing, Simone; Jia, Xiaoxiao; Günther, Patrick; Wheatley, Adam K; Kent, Stephen J; Aban, Malet; Deng, Yi-Mo; Laurie, Karen L; Hurt, Aeron C; Gras, Stephanie; Rossjohn, Jamie; Crowe, Jane; Xu, Jianqing; Jackson, David; Brown, Lorena E; La Gruta, Nicole; Chen, Weisan; Doherty, Peter C; Turner, Stephen J; Kotsimbos, Tom C; Thomas, Paul G; Cheng, Allen C; Kedzierska, Katherine.
Afiliação
  • Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Koutsakos M; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • van de Sandt CE; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Crawford JC; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
  • Loh L; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Sant S; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Grzelak L; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Allen EK; Biology Department, École Normale Supérieure Paris-Saclay, Université Paris-Saclay Cachan, Cachan, France.
  • Brahm T; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Clemens EB; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Auladell M; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Hensen L; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Wang Z; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Nüssing S; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Jia X; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Günther P; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Wheatley AK; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Kent SJ; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Aban M; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Deng YM; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia.
  • Laurie KL; ARC Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, VIC, Australia.
  • Hurt AC; World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Gras S; World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Rossjohn J; World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Crowe J; World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Xu J; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Jackson D; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.
  • Brown LE; Department of Biochemistry and Genetics, La Trobe Institute For Molecular Science, La Trobe University, Bundoora, VIC, Australia.
  • La Gruta N; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Chen W; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.
  • Doherty PC; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
  • Turner SJ; Deepdene Surgery, Deepdene, VIC, Australia.
  • Kotsimbos TC; Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
  • Thomas PG; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Cheng AC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
  • Kedzierska K; Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Nat Commun ; 12(1): 2691, 2021 05 11.
Article em En | MEDLINE | ID: mdl-33976217
How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one single study. Here, we utilize longitudinal samples from patients hospitalized with acute influenza to understand these immune responses. We report the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels. Influenza disease correlates with increases in IL-6/IL-8/MIP-1α/ß cytokines and lower antibody responses. Robust activation of circulating T follicular helper cells correlates with peak antibody-secreting cells and influenza heamaglutinin-specific memory B-cell numbers, which phenotypically differs from vaccination-induced B-cell responses. Numbers of influenza-specific CD8+ or CD4+ T cells increase early in disease and retain an activated phenotype during patient recovery. We report the characterisation of immune cellular networks underlying recovery from influenza infection which are highly relevant to other infectious diseases.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T CD4-Positivos / Citocinas / Linfócitos T Auxiliares-Indutores / Linfócitos T CD8-Positivos / Influenza Humana / Formação de Anticorpos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Humans / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T CD4-Positivos / Citocinas / Linfócitos T Auxiliares-Indutores / Linfócitos T CD8-Positivos / Influenza Humana / Formação de Anticorpos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Humans / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália