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RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.
Carr, Ryan M; Vorobyev, Denis; Lasho, Terra; Marks, David L; Tolosa, Ezequiel J; Vedder, Alexis; Almada, Luciana L; Yurcheko, Andrey; Padioleau, Ismael; Alver, Bonnie; Coltro, Giacomo; Binder, Moritz; Safgren, Stephanie L; Horn, Isaac; You, Xiaona; Solary, Eric; Balasis, Maria E; Berger, Kurt; Hiebert, James; Witzig, Thomas; Buradkar, Ajinkya; Graf, Temeida; Valent, Peter; Mangaonkar, Abhishek A; Robertson, Keith D; Howard, Matthew T; Kaufmann, Scott H; Pin, Christopher; Fernandez-Zapico, Martin E; Geissler, Klaus; Droin, Nathalie; Padron, Eric; Zhang, Jing; Nikolaev, Sergey; Patnaik, Mrinal M.
Afiliação
  • Carr RM; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Vorobyev D; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, MN, USA.
  • Lasho T; INSERM U981, Gustave Roussy Cancer Center, Villejuif, France.
  • Marks DL; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Tolosa EJ; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, MN, USA.
  • Vedder A; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, MN, USA.
  • Almada LL; Chemical Biology and Molecular Medicine Program, Moffitt Cancer Center, Tampa, FL, USA.
  • Yurcheko A; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, MN, USA.
  • Padioleau I; INSERM U981, Gustave Roussy Cancer Center, Villejuif, France.
  • Alver B; INSERM U981, Gustave Roussy Cancer Center, Villejuif, France.
  • Coltro G; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, MN, USA.
  • Binder M; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Safgren SL; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Horn I; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, MN, USA.
  • You X; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, MN, USA.
  • Solary E; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.
  • Balasis ME; INSERM U1170 and Department of Hematology, Gustave Roussy Cancer Center, Villejuif, France.
  • Berger K; Chemical Biology and Molecular Medicine Program, Moffitt Cancer Center, Tampa, FL, USA.
  • Hiebert J; London Regional Transgenic and Gene Targeting Facility, Lawson Health Research Institute University of Western Ontario, London, ON, Canada.
  • Witzig T; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Buradkar A; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Graf T; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Valent P; 5TH Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
  • Mangaonkar AA; 5TH Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
  • Robertson KD; Ludwig Boltzmann Institute for Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
  • Howard MT; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Kaufmann SH; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, MN, USA.
  • Pin C; Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, USA.
  • Fernandez-Zapico ME; Division of Hematology, Department of Internal Medicine, Mayo Clinic, MN, USA.
  • Geissler K; London Regional Transgenic and Gene Targeting Facility, Lawson Health Research Institute University of Western Ontario, London, ON, Canada.
  • Droin N; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, MN, USA.
  • Padron E; Sigmund Freud University Vienna, Vienna, Austria.
  • Zhang J; INSERM U1170 and Department of Hematology, Gustave Roussy Cancer Center, Villejuif, France.
  • Nikolaev S; Chemical Biology and Molecular Medicine Program, Moffitt Cancer Center, Tampa, FL, USA.
  • Patnaik MM; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.
Nat Commun ; 12(1): 2901, 2021 05 18.
Article em En | MEDLINE | ID: mdl-34006870
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Leucemia Mielomonocítica Crônica / Histona-Lisina N-Metiltransferase / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Proteína de Leucina Linfoide-Mieloide / GTP Fosfo-Hidrolases / Proteínas de Membrana / Mutação Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Leucemia Mielomonocítica Crônica / Histona-Lisina N-Metiltransferase / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Proteína de Leucina Linfoide-Mieloide / GTP Fosfo-Hidrolases / Proteínas de Membrana / Mutação Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos