Notch-Rho-cGMP interaction: common point of convergence in microvascular aging-related disease.
Clin Sci (Lond)
; 135(10): 1209-1212, 2021 05 28.
Article
em En
| MEDLINE
| ID: mdl-34014259
ABSTRACT
Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3-Rho kinase-cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
CADASIL
/
Insuficiência Cardíaca
Limite:
Humans
Idioma:
En
Revista:
Clin Sci (Lond)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Holanda