Epigenetic alterations of TGFß and its main canonical signaling mediators in the context of cardiac fibrosis.
J Mol Cell Cardiol
; 159: 38-47, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34119506
ABSTRACT
Cardiac fibrosis is a pathological process that presents a continuous overproduction of extracellular matrix (ECM) components in the myocardium, which negatively influences the progression of many cardiac diseases. Transforming growth factor ß (TGFß) is the main ligand that triggers the production of pro-fibrotic ECM proteins. In the cardiac fibrotic process, TGFß and its canonical signaling mediators are tightly regulated at different levels as well as epigenetically. Cardiac fibroblasts are one of the most important TGFß target cells activated after cardiac injury. TGFß-driven fibroblast activation is subject to epigenetic modulation and contributes to the progression of cardiac fibrosis, mainly through the expression of pro-fibrotic molecules implicated in the disease. In this review, we describe epigenetic regulation related to canonical TGFß signaling in cardiac fibroblasts.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fibrose
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Transdução de Sinais
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Fator de Crescimento Transformador beta
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Epigênese Genética
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Coração
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Miocárdio
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Mol Cell Cardiol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Espanha