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Genetic Causes of Hearing Loss in a Large Cohort of Cochlear Implant Recipients.
Seligman, Kristen L; Shearer, A Eliot; Frees, Kathy; Nishimura, Carla; Kolbe, Diana; Dunn, Camille; Hansen, Marlan R; Gantz, Bruce J; Smith, Richard J H.
Afiliação
  • Seligman KL; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  • Shearer AE; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  • Frees K; Boston Children's Hospital, Department of Otolaryngology & Communication Enhancement, Harvard Medical School, Boston, Massachusetts, USA.
  • Nishimura C; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  • Kolbe D; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  • Dunn C; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  • Hansen MR; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  • Gantz BJ; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
  • Smith RJH; Department of Otolaryngology-Head & Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Otolaryngol Head Neck Surg ; 166(4): 734-737, 2022 04.
Article em En | MEDLINE | ID: mdl-34154485
Understanding genetic causes of hearing loss can determine the pattern and course of a patient's hearing loss and may also predict outcomes after cochlear implantation. Our goal in this study was to evaluate genetic causes of hearing loss in a large cohort of adults and children with cochlear implants. We performed comprehensive genetic testing on all patients undergoing cochlear implantation. Of the 459 patients included in the study, 128 (28%) had positive genetic testing. In total, 44 genes were identified as causative. The top 5 genes implicated were GJB2 (20, 16%), TMPRSS3 (13, 10%), SLC26A4 (10, 8%), MYO7A (9, 7%), and MT-RNR1 (7, 5%). Pediatric patients had a higher diagnostic rate. This study lays the groundwork for future studies evaluating the relationship between genetic variation and cochlear implant performance.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Implantes Cocleares / Implante Coclear / Surdez / Perda Auditiva Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Humans Idioma: En Revista: Otolaryngol Head Neck Surg Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Implantes Cocleares / Implante Coclear / Surdez / Perda Auditiva Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Humans Idioma: En Revista: Otolaryngol Head Neck Surg Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos