CD-g-CS nanoparticles for enhanced antibiotic treatment of Staphylococcus xylosus infection.
Microb Biotechnol
; 15(2): 535-547, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34180582
ABSTRACT
Staphylococcus xylosus (S. xylosus)-induced cow mastitis is an extremely serious clinical problem. However, antibiotic therapy does not successfully treat S. xylosus infection because these bacteria possess a strong biofilm formation ability, which significantly reduces the efficacy of antibiotic treatments. In this study, we developed ceftiofur-loaded chitosan grafted with ß-cyclodextrins (CD-g-CS) nanoparticles (CT-NPs) using host-guest interaction. These positively charged nanoparticles improved bacterial internalization, thereby significantly improving the effectiveness of antibacterial treatments for planktonic S. xylosus. Moreover, CT-NPs effectively inhibited biofilm formation and eradicated mature biofilms. After mammary injection in a murine model of S. xylosus-induced mastitis, CT-NPs significantly reduced bacterial burden and alleviated inflammation, thereby achieving optimized therapeutic efficiency for S. xylosus infection. In conclusion, this treatment strategy could improve the efficiency of antibiotic therapeutics and shows great potential in the treatment of S. xylosus infections.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Nanopartículas
/
Mastite
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Microb Biotechnol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China