Chromatin mobility and relocation in DNA repair.
Trends Cell Biol
; 31(10): 843-855, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34183232
ABSTRACT
The nucleus is a dynamic environment containing chromatin, membraneless organelles, and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA repair activities are observations of increased mobility of damaged chromatin and the displacement of DNA lesions to specific nuclear environments. Here, we focus on the role that nuclear-specific filamentous actin plays in mobilizing damaged chromatin in response to DNA double-strand breaks and replication stress. We also examine nuclear pore complexes and promyelocytic leukemia-nuclear bodies as specialized platforms for homology-directed repair. The literature suggests an emerging model where specific types of DNA lesions are subjected to nuclear-derived forces that mobilize damaged chromatin and promote interaction with repair hubs to facilitate specialized repair reactions.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Cromatina
/
Condensados Biomoleculares
Limite:
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália