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Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
Ducimetière, Laura; Lucchiari, Giulia; Litscher, Gioana; Nater, Marc; Heeb, Laura; Nuñez, Nicolás Gonzalo; Wyss, Laura; Burri, Dominik; Vermeer, Marijne; Gschwend, Julia; Moor, Andreas E; Becher, Burkhard; van den Broek, Maries; Tugues, Sonia.
Afiliação
  • Ducimetière L; Innate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Lucchiari G; Tumor Immunology, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Litscher G; Innate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Nater M; Tumor Immunology, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Heeb L; Innate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Nuñez NG; Inflammation Research, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Wyss L; Tumor Immunology, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Burri D; Tumor Immunology, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Vermeer M; Innate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Gschwend J; Innate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • Moor AE; Institute of Molecular Cancer Research, University of Zurich, CH-8057 Zurich, Switzerland.
  • Becher B; Inflammation Research, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.
  • van den Broek M; Tumor Immunology, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland; vandenbroek@immunology.uzh.ch tugues@immunology.uzh.ch.
  • Tugues S; Innate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland; vandenbroek@immunology.uzh.ch tugues@immunology.uzh.ch.
Proc Natl Acad Sci U S A ; 118(27)2021 07 06.
Article em En | MEDLINE | ID: mdl-34183415
ABSTRACT
The liver is a major metastatic target organ, and little is known about the role of immunity in controlling hepatic metastases. Here, we discovered that the concerted and nonredundant action of two innate lymphocyte subpopulations, conventional natural killer cells (cNKs) and tissue-resident type I innate lymphoid cells (trILC1s), is essential for antimetastatic defense. Using different preclinical models for liver metastasis, we found that trILC1 controls metastatic seeding, whereas cNKs restrain outgrowth. Whereas the killing capacity of trILC1s was not affected by the metastatic microenvironment, the phenotype and function of cNK cells were affected in a cancer type-specific fashion. Thus, individual cancer cell lines orchestrate the emergence of unique cNK subsets, which respond differently to tumor-derived factors. Our findings will contribute to the development of therapies for liver metastasis involving hepatic innate cells.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Linfócitos / Imunidade Inata / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Linfócitos / Imunidade Inata / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça