The azithromycin to prevent wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population.

Srinivasan, Mythili; Bacharier, Leonard B; Goss, Charles W; Zhou, Yanjiao; Boomer, Jonathan; Bram, Sarah; Burgdorf, Dana; Burnham, Carey-Ann; Casper, Timothy; Castro, Mario; Coverstone, Andrea; Haslam, Matthew; Kanchongkittiphon, Watcharoot; Kuklinski, Cadence; Lian, Qinghua; Schechtman, Kenneth; Storch, Gregory A; True, Kelly; Wallace, Meghan A; Yin-DeClue, Huiqing; Ahrens, Elizabeth; Wang, Jinli; Beigelman, Avraham

Srinivasan, Mythili; Bacharier, Leonard B; Goss, Charles W; Zhou, Yanjiao; Boomer, Jonathan; Bram, Sarah; Burgdorf, Dana; Burnham, Carey-Ann; Casper, Timothy; Castro, Mario; Coverstone, Andrea; Haslam, Matthew; Kanchongkittiphon, Watcharoot; Kuklinski, Cadence; Lian, Qinghua; Schechtman, Kenneth; Storch, Gregory A; True, Kelly; Wallace, Meghan A; Yin-DeClue, Huiqing; Ahrens, Elizabeth; Wang, Jinli; Beigelman, Avraham.

Afiliação

Srinivasan M; Division of Hospitalist Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Bacharier LB; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Goss CW; Division of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Zhou Y; Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
Boomer J; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Bram S; Division of Hospitalist Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Burgdorf D; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Burnham CA; Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, CAB, USA.
Casper T; Division of Hospitalist Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Castro M; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Coverstone A; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Haslam M; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Kanchongkittiphon W; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Kuklinski C; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Lian Q; Division of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Schechtman K; Division of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Storch GA; Division of Pediatric Infectious Disease, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
True K; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Wallace MA; Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, CAB, USA.
Yin-DeClue H; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Ahrens E; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Wang J; Division of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
Beigelman A; Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.

Contemp Clin Trials Commun ; 22: 100798, 2021 Jun.

Article em En | MEDLINE | ID: mdl-34189338

Palavras-chave

AE, Adverse events; AESI, AEs of Special Interest; APW, Azithromycin to Prevent Wheezing; AZM, Azithromycin; Asthma; Azithromycin; DSMB, Data safety and monitoring board; ED, Emergency department; ICS, Inhaled corticosteroids; IL, Interleukin; IRB, Institutional review board; LRTI, Lower respiratory tract infection; MMP-9, Matrix metallopeptidase-9; Microbiome; NHLBI, National Heart, Lung, and Blood Institute; PC, Phone call; RBEL, RSV Bronchiolitis in Early Life; RSV, Respiratory syncytial virus; RW, Recurrent wheezing; RZ, Randomization; Recurrent wheezing; Respiratory syncytial virus (RSV) bronchiolitis; SAE, serious adverse events; SLCH, Saint Louis Children's Hospital; V, visit

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Contemp Clin Trials Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google