Optimal umbilical cord blood collection, processing and cryopreservation methods for sustained public cord blood banking.
Cytotherapy
; 23(11): 1029-1035, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34247985
ABSTRACT
BACKGROUND AIMS:
Umbilical cord blood is an established source of stem cells in patients with hematologic malignancies who do not have HLA-compatible matched related or unrelated donors. The success of an umbilical cord blood transplant depends on the dose of total nucleated and CD34+ cells infused. Therefore, collecting, banking and listing high-quality cord blood units with high total nucleated and CD34+ cell dose are essential.METHODS:
Here the authors describe their cord blood bank's novel collection technique, which involves both in utero and ex utero collection of a single cord blood unit. The authors also evaluated maternal, neonatal and collection parameters that may impact the cell dose.RESULTS:
Maternal gestational age and race, and neonatal weight and sex correlated with the total nucleated cell dose.CONCLUSIONS:
The optimized collection of umbilical cord blood is critical for its use as a source of stem cells for transplantation.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bancos de Sangue
/
Transplante de Células-Tronco de Sangue do Cordão Umbilical
Limite:
Humans
Idioma:
En
Revista:
Cytotherapy
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos