Sex Differences in Functional Connectivity Between Resting State Brain Networks in Autism Spectrum Disorder.
J Autism Dev Disord
; 52(7): 3088-3101, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-34272649
ABSTRACT
Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD-in suggestive compatibility with ASD cognitive and neuroscientific theories.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transtorno do Espectro Autista
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Autism Dev Disord
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Portugal