The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-ß type I receptor degradation.

Sun, Yang; Li, Zi-Jian

Sun, Yang; Li, Zi-Jian.

Afiliação

Sun Y; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China.
Li ZJ; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China. lizijian@bjmu.edu.cn.

Acta Pharmacol Sin ; 43(3): 634-644, 2022 Mar.

Article em En | MEDLINE | ID: mdl-34331017

Assuntos

Proteínas dos Microfilamentos/metabolismo; Proteína Smad7/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Animais; Proteína Axina/metabolismo; Linhagem Celular; Fibroblastos; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Transdução de Sinais/fisiologia; Domínios de Homologia de src

Palavras-chave

HIP-55; Smad7; TGF-ß signalling-related human diseases; TGF-ß type I receptor; degradation

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteína Smad7 / Fator de Crescimento Transformador beta1 / Proteínas dos Microfilamentos Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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