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The role of the Cer1 transposon in horizontal transfer of transgenerational memory.
Moore, Rebecca S; Kaletsky, Rachel; Lesnik, Chen; Cota, Vanessa; Blackman, Edith; Parsons, Lance R; Gitai, Zemer; Murphy, Coleen T.
Afiliação
  • Moore RS; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Kaletsky R; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; LSI Genomics, Princeton University, Princeton, NJ 08544, USA.
  • Lesnik C; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; LSI Genomics, Princeton University, Princeton, NJ 08544, USA.
  • Cota V; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Blackman E; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Parsons LR; LSI Genomics, Princeton University, Princeton, NJ 08544, USA.
  • Gitai Z; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Murphy CT; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; LSI Genomics, Princeton University, Princeton, NJ 08544, USA. Electronic address: ctmurphy@princeton.edu.
Cell ; 184(18): 4697-4712.e18, 2021 09 02.
Article em En | MEDLINE | ID: mdl-34363756
Animals face both external and internal dangers: pathogens threaten from the environment, and unstable genomic elements threaten from within. C. elegans protects itself from pathogens by "reading" bacterial small RNAs, using this information to both induce avoidance and transmit memories for four generations. Here, we found that memories can be transferred from either lysed animals or from conditioned media to naive animals via Cer1 retrotransposon-encoded virus-like particles. Moreover, Cer1 functions internally at the step of transmission of information from the germline to neurons and is required for learned avoidance. The presence of the Cer1 retrotransposon in wild C. elegans strains correlates with the ability to learn and inherit small-RNA-induced pathogen avoidance. Together, these results suggest that C. elegans has co-opted a potentially dangerous retrotransposon to instead protect itself and its progeny from a common pathogen through its inter-tissue signaling ability, hijacking this genomic element for its own adaptive immunity benefit.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Elementos de DNA Transponíveis / Transferência Genética Horizontal / Padrões de Herança / Memória Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Elementos de DNA Transponíveis / Transferência Genética Horizontal / Padrões de Herança / Memória Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos