Total vascular resistance, augmentation index, and augmentation pressure increase in patients with peripheral artery disease.
Medicine (Baltimore)
; 100(32): e26931, 2021 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-34397939
ABSTRACT
ABSTRACT Peripheral arterial disease (PAD) is one of major vascular diseases which frequently coexists with coronary arterial disease and cerebrovascular disease. The patients with PAD have a poor prognosis when it progresses. A new blood pressure testing device enables to simultaneously measure brachial blood pressure (BP), central BP, and several vascular parameters, with easy and non-invasive, in a short time. Here, we aimed to evaluate these arterial stiffness parameters in patients with PAD.In this study, 243 consecutive patients who were suspected of having PAD and referred to our hospital from September 2016 to June 2019, were registered. Several parameters, such as brachial BP, central BP, aortic pulse wave velocity (aPWV), total vascular resistance (TVR), augmentation index (AI) and augmentation pressure (AP), were determined by Mobil-O-Graph. Ankle-brachial pressure index (ABI) was used to define PAD (ABIâ≤â0.9 as PAD). The relationship between PAD and central BP, aPWV, TVR, AI, or AP were investigated.One hundred sixty-two patients (67%) were categorized as the PAD group and 81 patients (33%) as the non-PAD group. In the PAD group, the systolic brachial BP and central systolic BP were significantly higher than those in the non-PAD group (138â±â24âmmHg vs 131â±â19âmmHg, Pâ<â.05, 125â±â22âmmHg vs 119â±â18 mmHg, Pâ<â.05, respectively). TVR, AI, and AP were significantly higher in the PAD group (1785â±â379âdynâs/cm5 vs 1661â±â317âdynâs/cm5, Pâ<â.05, 26.2â±â13.0% vs 22.2â±â13.3%, Pâ<â.05, 13.5â±â9.4âmmHg vs 10.7â±â7.2âmmHg, Pâ<â.05, respectively). No significant differences in diastolic BP, central diastolic BP, and aPWV were found between the groups. Multivariate logistic regression analysis revealed that PAD was significantly associated with TVR, AI, and AP (Pâ<â.05, respectively).TVR/AP/AI were significantly higher in the PAD group than in the non-PAD group.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Resistência Vascular
/
Velocidade do Fluxo Sanguíneo
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Pressão Sanguínea
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Doença Arterial Periférica
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Rigidez Vascular
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão