Determining a healthy reference range and factors potentially influencing PRO-C3 - A biomarker of liver fibrosis.

Erhardtsen, Elisabeth; Rasmussen, Daniel G K; Frederiksen, Peder; Leeming, Diana Julie; Shevell, Diane; Gluud, Lise Lotte; Karsdal, Morten Asser; Aithal, Guruprasad P; Schattenberg, Jörn M

Erhardtsen, Elisabeth; Rasmussen, Daniel G K; Frederiksen, Peder; Leeming, Diana Julie; Shevell, Diane; Gluud, Lise Lotte; Karsdal, Morten Asser; Aithal, Guruprasad P; Schattenberg, Jörn M.

Afiliação

Erhardtsen E; Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
Rasmussen DGK; Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
Frederiksen P; Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
Leeming DJ; Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
Shevell D; Innovative Medicine, Bristol Myers-Squibb, Princeton, NJ, USA.
Gluud LL; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Karsdal MA; Gastro Unit, Medical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
Aithal GP; Nordic Bioscience Biomarkers and Research, Herlev, Denmark.
Schattenberg JM; Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.

JHEP Rep ; 3(4): 100317, 2021 Aug.

Article em En | MEDLINE | ID: mdl-34466796

Palavras-chave

ADAM, A Disintegrin and Metalloproteases; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC, area under the receiver operating characteristics curve; Biomarkers; Biopsy; Body mass index; CLSI, Clinical and Laboratory Standards Institute; Collagen type III; ELF™ test, Enhanced Liver Fibrosis test; Ethnic groups; FIB-4, fibrosis-4; Fibrosis; Healthy volunteers; Hospitals; Humans; LITMUS, Liver Investigation: Testing Marker Utility in Steatohepatitis (consortium); NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD Activity Score; NASH, non-alcoholic steatohepatitis; NASH-CRN, NASH Clinical Research Network; NIMBLE, Non-Invasive Biomarkers of Metabolic Liver Disease (consortium); NPV, negative predictive value; Non-alcoholic fatty liver disease; PPV, positive predictive value; Reference standards; Reference values; T2DM, type 2 diabetes mellitus

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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: JHEP Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca

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