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IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver.
Zhao, Li-Na; Yuan, Hong-Feng; Wang, Yu-Fei; Yun, Hao-Lin; Zheng, Wei; Yuan, Ying; Geng, Yu; Zhao, Man; Feng, Lian-Yun; Zhang, Xiao-Dong.
Afiliação
  • Zhao LN; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Yuan HF; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Wang YF; Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China.
  • Yun HL; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Zheng W; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Yuan Y; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Geng Y; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Zhao M; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Feng LY; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • Zhang XD; Department of Cancer Research, Institute of Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071, China.
Acta Pharmacol Sin ; 43(6): 1484-1494, 2022 Jun.
Article em En | MEDLINE | ID: mdl-34497374
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China