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Relationship between transfusion burden, healthcare resource utilization, and complications in patients with beta-thalassemia in Taiwan: A real-world analysis.
Tang, Chao-Hsiun; Furnback, Wesley; Wang, Bruce C M; Tang, Jackson; Tang, Derek; Lu, Meng-Yao; Huang, Vicky W-H; Musallam, Khaled M.
Afiliação
  • Tang CH; School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan.
  • Furnback W; Elysia Group, LLC, New York, New York, USA.
  • Wang BCM; Elysia Group, LLC, New York, New York, USA.
  • Tang J; Asclepius Analytics Ltd, New York, New York, USA.
  • Tang D; Bristol Myers Squibb, Princeton, New Jersey, USA.
  • Lu MY; Department of Paediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Huang VW; Bristol Myers Squibb, Princeton, New Jersey, USA.
  • Musallam KM; International Network of Haematology, London, UK.
Transfusion ; 61(10): 2906-2917, 2021 10.
Article em En | MEDLINE | ID: mdl-34505291
ABSTRACT

BACKGROUND:

This study utilized a population-based claims database to identify patients with beta-thalassemia and evaluate associations between transfusion burden, healthcare resource utilization (HCRU), and complications. STUDY DESIGN AND

METHODS:

Taiwan's National Health Insurance Research Database was used to identify patients with beta-thalassemia (ICD-10 D56.1) in 2016. Patients with a beta-thalassemia claim in 2016 were indexed into the study at their first claim on or after January 1, 2001 in the dataset through to December 31, 2016 and followed until the end of study. During the follow-up period, red blood cell transfusion (RBCT) units, HCRU, iron chelation therapy use, and beta-thalassemia-related complications incidence were recorded. Patients were grouped into transfusion burden severity cohorts based on average number of RBCT units per 12 weeks during follow-up 0 RBCT units, >0 to <6 RBCT units (mild), ≥6 to <12 RBCT units (moderate), and ≥12 RBCT units (severe).

RESULTS:

A total of 2984 patients were included with mean follow-up of 6.95 years. Of these, 1616 (54.2%) patients had no claims for RBCT units, 1112 (37.3%) had claims for >0 to <6 RBCT units, 112 (3.8%) for ≥6 to <12 RBCT units, and 144 (4.8%) for ≥12 RBCT units per 12 weeks. Transfused patients had significantly more all-cause HCRU and iron chelation therapy compared with non-transfused patients during follow-up. Thalassemia-related HCRU and risk of liver, endocrine, cardiac, and renal complications were significantly and positively correlated with increases of RBCT units.

DISCUSSION:

Clinical and healthcare resource burden of patients with beta-thalassemia is closely related to transfusion burden.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Transfusão de Sangue / Talassemia beta Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Transfusion Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Transfusão de Sangue / Talassemia beta Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Transfusion Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Taiwan