Vitamin D Supplementation Improves Fasting Insulin Levels and HDL Cholesterol in Infertile Men.
J Clin Endocrinol Metab
; 107(1): 98-108, 2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-34508607
ABSTRACT
CONTEXT Vitamin D has been linked with glucose and lipid metabolism. Men with impaired gonadal function have a higher risk of metabolic syndrome and mortality, and vitamin D status may be a reversible modulator. OBJECTIVE:
This work aimed to determine the effect of daily vitamin D and calcium supplementation for 150 days on glucose and lipid homeostasis in infertile men.METHODS:
A single-center, double-blinded, randomized clinical trial (NCT01304927) was conducted. A total of 307 infertile men were randomly assigned (11) to a single dose of 300â 000 IU cholecalciferol followed by 1400 IU cholecalciferolâ +â 500 mg of calcium daily (nâ =â 151) or placebo (nâ =â 156) for 150 days. Reported metabolic parameters including fasting plasma glucose, glycated hemoglobin A1c, fasting serum insulin, homeostatic model assessment of insulin resistance (HOMA-IR), fasting plasma cholesterols, and triglycerides were secondary end points. The primary end point semen quality has previously been reported.RESULTS:
Men receiving vitamin D supplementation improved their vitamin D status, whereas vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone. At the end of the trial, men receiving vitamin D supplementation had 13% lower fasting serum insulin concentrations compared with the placebo-treated group (65 vs 74 pmol/L, Pâ =â .018) and 19% lower HOMA-IR (2.2 vs 2.7, Pâ =â .025). Moreover, men in the vitamin D group had higher high-density lipoprotein (HDL) cholesterol levels (1.38 vs 1.32 mmol/L, Pâ =â .008) compared with the placebo group.CONCLUSION:
High-dose vitamin D supplementation has beneficial effects on glucose homeostasis and HDL cholesterol levels in infertile men.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina D
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Colecalciferol
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Suplementos Nutricionais
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Infertilidade Masculina
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Insulina
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Prognostic_studies
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Dinamarca