Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1ß Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells.

Surabhi, Surabhi; Jachmann, Lana H; Shumba, Patience; Burchhardt, Gerhard; Hammerschmidt, Sven; Siemens, Nikolai

Surabhi, Surabhi; Jachmann, Lana H; Shumba, Patience; Burchhardt, Gerhard; Hammerschmidt, Sven; Siemens, Nikolai.

Afiliação

Surabhi S; Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Jachmann LH; Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Shumba P; Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Burchhardt G; Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Hammerschmidt S; Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Siemens N; Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.

J Innate Immun ; 14(3): 192-206, 2022.

Article em En | MEDLINE | ID: mdl-34515145

Assuntos

Inflamassomos; Infecções Pneumocócicas; Caspase 1/metabolismo; Células Epiteliais/metabolismo; Humanos; Peróxido de Hidrogênio; Inflamassomos/metabolismo; Interleucina-1beta/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Piroptose; Streptococcus pneumoniae

Palavras-chave

Apoptosis; Caspase-1; Caspase-3/7; Cell death; IL-1ß; NLRP3 inflammasome; Pyroptosis; Streptococcus pneumoniae

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Infecções Pneumocócicas / Inflamassomos Limite: Humans Idioma: En Revista: J Innate Immun Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

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