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Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution.
Griesemer, Dustin; Xue, James R; Reilly, Steven K; Ulirsch, Jacob C; Kukreja, Kalki; Davis, Joe R; Kanai, Masahiro; Yang, David K; Butts, John C; Guney, Mehmet H; Luban, Jeremy; Montgomery, Stephen B; Finucane, Hilary K; Novina, Carl D; Tewhey, Ryan; Sabeti, Pardis C.
Afiliação
  • Griesemer D; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA 02115, USA; Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Xue JR; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02143, USA. Electronic address: jxue@broadinstitute.org.
  • Reilly SK; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02143, USA.
  • Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Kukreja K; Department of Molecular and Cell Biology, Harvard University, Cambridge, MA 02138, USA.
  • Davis JR; BigHat Biosciences, San Carlos, CA 94070, USA.
  • Kanai M; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA 02115, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Yang DK; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA.
  • Butts JC; The Jackson Laboratory, Bar Harbor, ME 04609, USA; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA.
  • Guney MH; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • Luban J; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • Montgomery SB; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Novina CD; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Tewhey R; The Jackson Laboratory, Bar Harbor, ME 04609, USA; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA; Tufts University School of Medicine, Boston, MA 02111, USA.
  • Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02143, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Cell ; 184(20): 5247-5260.e19, 2021 09 30.
Article em En | MEDLINE | ID: mdl-34534445
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doença / Regiões 3' não Traduzidas / Evolução Biológica / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doença / Regiões 3' não Traduzidas / Evolução Biológica / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos