Modification Strategy of D-leucine Residue Addition on a Novel Peptide from <i>Odorrana schmackeri</i>, with Enhanced Bioactivity and In Vivo Efficacy.

Yao, Aifang; Ma, Yingxue; Chen, Xiaoling; Zhou, Mei; Xi, Xinping; Ma, Chengbang; Ren, Shen; Chen, Tianbao; Shaw, Chris; Wang, Lei

Modification Strategy of D-leucine Residue Addition on a Novel Peptide from Odorrana schmackeri, with Enhanced Bioactivity and In Vivo Efficacy.

Yao, Aifang; Ma, Yingxue; Chen, Xiaoling; Zhou, Mei; Xi, Xinping; Ma, Chengbang; Ren, Shen; Chen, Tianbao; Shaw, Chris; Wang, Lei.

Afiliação

Yao A; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Ma Y; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Chen X; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Zhou M; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Xi X; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Ma C; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Ren S; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Chen T; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Shaw C; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Wang L; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

Toxins (Basel) ; 13(9)2021 08 31.

Article em En | MEDLINE | ID: mdl-34564615

Assuntos

Proteínas de Anfíbios/farmacologia; Antibacterianos/farmacologia; Peptídeos Catiônicos Antimicrobianos/farmacologia; Bactérias Gram-Positivas/efeitos dos fármacos; Leucina/química; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Ranidae; Proteínas de Anfíbios/química; Animais; Antibacterianos/química; Peptídeos Catiônicos Antimicrobianos/química; Bactérias Gram-Positivas/fisiologia; Staphylococcus aureus Resistente à Meticilina/fisiologia; Mariposas/microbiologia

Palavras-chave

D-leucine peptide; antimicrobial peptide (AMP); brevinin; cytotoxicity; dual antibacterial and anticancer activities

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ranidae / Peptídeos Catiônicos Antimicrobianos / Proteínas de Anfíbios / Staphylococcus aureus Resistente à Meticilina / Bactérias Gram-Positivas / Leucina / Antibacterianos Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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