Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression.

Li, Xiang; Gohain, Neelakshi; Chen, Si; Li, Yinghua; Zhao, Xiaoyuan; Li, Bo; Tolbert, William D; He, Wangxiao; Pazgier, Marzena; Hu, Honggang; Lu, Wuyuan

Li, Xiang; Gohain, Neelakshi; Chen, Si; Li, Yinghua; Zhao, Xiaoyuan; Li, Bo; Tolbert, William D; He, Wangxiao; Pazgier, Marzena; Hu, Honggang; Lu, Wuyuan.

Afiliação

Li X; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Gohain N; Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Chen S; Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Li Y; School of Medicine, Shanghai University, Shanghai 200444, China.
Zhao X; Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Li B; Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Tolbert WD; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
He W; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Pazgier M; Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Hu H; Department of Talent Highland, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Lu W; Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Acta Pharm Sin B ; 11(9): 2655-2669, 2021 Sep.

Article em En | MEDLINE | ID: mdl-34589387

Palavras-chave

Antitumor peptide; FP, fluorescence polarization; ITC, isothermal titration calorimetry; MDM2; MDM2, murine double minute 2; MDMX; MDMX, murine double minute X; P53; PMI, P53âMDM2/MDMX inhibitor; SAR, structureâactivity relationship; SPR, surface plasmon resonance; Systematic mutational analysis

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China