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MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia.
Sanjiv, Kumar; Calderón-Montaño, José Manuel; Pham, Therese M; Erkers, Tom; Tsuber, Viktoriia; Almlöf, Ingrid; Höglund, Andreas; Heshmati, Yaser; Seashore-Ludlow, Brinton; Nagesh Danda, Akhilesh; Gad, Helge; Wiita, Elisee; Göktürk, Camilla; Rasti, Azita; Friedrich, Stefanie; Centio, Anders; Estruch, Montserrat; Våtsveen, Thea Kristin; Struyf, Nona; Visnes, Torkild; Scobie, Martin; Koolmeister, Tobias; Henriksson, Martin; Wallner, Olov; Sandvall, Teresa; Lehmann, Sören; Theilgaard-Mönch, Kim; Garnett, Mathew J; Östling, Päivi; Walfridsson, Julian; Helleday, Thomas; Warpman Berglund, Ulrika.
Afiliação
  • Sanjiv K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Calderón-Montaño JM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Pham TM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Erkers T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Tsuber V; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Almlöf I; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Höglund A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Heshmati Y; Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  • Seashore-Ludlow B; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Nagesh Danda A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Gad H; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Göktürk C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Rasti A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Friedrich S; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Centio A; The Finsen Laboratory, Rigshospitalet/National University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Estruch M; Biotech Research and Innovation Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Våtsveen TK; The Finsen Laboratory, Rigshospitalet/National University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Struyf N; Biotech Research and Innovation Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Visnes T; Department for Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
  • Scobie M; KG Jebsen Center for B cell malignancies, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Koolmeister T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Henriksson M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Sandvall T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Lehmann S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Theilgaard-Mönch K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Garnett MJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  • Östling P; Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  • Walfridsson J; Department of Medical Sciences, Haematology, Uppsala University, Uppsala, Sweden.
  • Helleday T; The Finsen Laboratory, Rigshospitalet/National University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Warpman Berglund U; Biotech Research and Innovation Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cancer Res ; 81(22): 5733-5744, 2021 11 15.
Article em En | MEDLINE | ID: mdl-34593524
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pirimidinas / Células-Tronco Neoplásicas / Leucemia Mieloide Aguda / Crise Blástica / Regulação Leucêmica da Expressão Gênica / Monoéster Fosfórico Hidrolases / Enzimas Reparadoras do DNA / Mitose Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suécia
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pirimidinas / Células-Tronco Neoplásicas / Leucemia Mieloide Aguda / Crise Blástica / Regulação Leucêmica da Expressão Gênica / Monoéster Fosfórico Hidrolases / Enzimas Reparadoras do DNA / Mitose Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suécia