Serum osteocalcin levels at 4 months of age were associated with neurodevelopment at 4 years of age in term-born children.
Acta Paediatr
; 111(2): 338-345, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34647329
ABSTRACT
AIM:
The hormone osteocalcin influenced neurodevelopment and cognition in mice models; this human study explored potential associations between total serum levels in human infants and neurodevelopment at 4 years of age.METHODS:
The data were based on two Swedish birth cohorts from 2008 to 2009. We followed 158 healthy full-term vaginal births (51% girls) by measuring serum osteocalcin in cord blood and at 4, 12 and 36 months. The values were compared with neurodevelopment tests at 4 years of age.RESULTS:
There was an association between osteocalcin at 4 months and later full-scale intelligence quotient (IQ; r2 0.031, p < 0.05). Children with osteocalcin levels in the highest quartile scored 5.6 (95% confidence interval [1.3, 9.9]) points higher than those in the lowest quartile, with mean scores of 118.8 ± 8.8 and 113.2 ± 9.2 (p < 0.05). They also scored higher on gross motor skills (p < 0.05) and showed greater ability during the drawing trail test (p < 0.005). Cord levels of osteocalcin were negatively associated with processing speed and fine motor development at 4 years, but levels at 12 and 36 months were not associated with later neurodevelopment.CONCLUSION:
Osteocalcin levels in infancy appeared to be associated with later IQ and motor development, but more research is needed.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Desenvolvimento Infantil
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Coorte de Nascimento
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Acta Paediatr
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Suécia