New Approaches to Glioblastoma.
Annu Rev Med
; 73: 279-292, 2022 01 27.
Article
em En
| MEDLINE
| ID: mdl-34665646
ABSTRACT
Faced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment for drug penetration and target engagement will inform go/no-go later-stage clinical studies. Innovative trial designs and analyses are needed to move effective agents toward regulatory approvals more rapidly.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Glioblastoma
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Med
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos