The Gut Microbiome: Connecting Diet, Glucose Homeostasis, and Disease.
Annu Rev Med
; 73: 469-481, 2022 01 27.
Article
em En
| MEDLINE
| ID: mdl-34678047
ABSTRACT
Type 2 diabetes rates continue to rise unabated, underscoring the need to better understand the etiology and potential therapeutic options available for this disease. The gut microbiome plays a role in glucose homeostasis, and diabetes is associated with alterations in the gut microbiome. Given that consumption of a Western diet is associated with increased metabolic disease, and that a Western diet alters the gut microbiome, it is plausible that changes in the gut microbiota mediate the dysregulation in glucose homeostasis. In this review, we highlight a few of the most significant mechanisms by which the gut microbiome can influence glucose regulation, including changes in gut permeability, gut-brain signaling, and production of bacteria-derived metabolites like short-chain fatty acids and bile acids. A better understanding of these pathways could lead to the development of novel therapeutics to target the gut microbiome in order to restore glucose homeostasis in metabolic disease.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Med
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos