The SGLT2-inhibitor dapagliflozin improves neutropenia and neutrophil dysfunction in a mouse model of the inherited metabolic disorder GSDIb.

Resaz, Roberta; Raggi, Federica; Segalerba, Daniela; Lavarello, Chiara; Gamberucci, Alessandra; Bosco, Maria Carla; Astigiano, Simonetta; Assunto, Antonia; Melis, Daniela; D'Acierno, Mariavittoria; Veiga-da-Cunha, Maria; Petretto, Andrea; Marcolongo, Paola; Trepiccione, Francesco; Eva, Alessandra

Resaz, Roberta; Raggi, Federica; Segalerba, Daniela; Lavarello, Chiara; Gamberucci, Alessandra; Bosco, Maria Carla; Astigiano, Simonetta; Assunto, Antonia; Melis, Daniela; D'Acierno, Mariavittoria; Veiga-da-Cunha, Maria; Petretto, Andrea; Marcolongo, Paola; Trepiccione, Francesco; Eva, Alessandra.

Afiliação

Resaz R; Laboratory of Molecular Biology, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Raggi F; Laboratory of Molecular Biology, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Segalerba D; Laboratory of Molecular Biology, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Lavarello C; Core Facilities-Clinical Proteomics and Metabolomics, IRCCS, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Gamberucci A; Department of Molecular and Developmental Medicine, Università degli Studi di Siena, Siena, Italy.
Bosco MC; Laboratory of Molecular Biology, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Astigiano S; Animal Facility, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Assunto A; Medical, Surgical, and Dental Department, Università degli Studi di Salerno, Salerno, Italy.
Melis D; Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana," Section of Pediatrics, Università degli Studi di Salerno, Via Salvador Allende, 43 84081, Baronissi, Salerno, Italy.
D'Acierno M; Biogem Research Institute "Gaetano Salvatore", Ariano Irpino, Italy.
Veiga-da-Cunha M; Department of Translational Medical Sciences, Università degli Studi della Campania "L. Vanvitelli", Naples, Italy.
Petretto A; Walloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium.
Marcolongo P; Groupe de Recherches Metaboliques, de Duve Institute, UCLouvain, (Université Catholique de Louvain), B-1200 Brussels, Belgium.
Trepiccione F; Core Facilities-Clinical Proteomics and Metabolomics, IRCCS, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Eva A; Department of Molecular and Developmental Medicine, Università degli Studi di Siena, Siena, Italy.

Mol Genet Metab Rep ; 29: 100813, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34712576

Palavras-chave

1,5-anhydroglucitol-6-phosphate; 1,5AG, 1,5-anhydroglucitol; 1,5AG6P, 1,5-anhydroglucitol-6-phosphate; BM, bone marrow; CFU, colony forming units; Dapagliflozin; G-CSF, granulocyte colony stimulating factor; G6PC3, glucose-6-phosphatase C3; G6PT, glucose-6-phospate translocase; GSDIb, Glycogen Storage Disease type 1b; Glycogen storage disease type 1b; M-CSF, macrophage colony stimulating factor; Mouse model; NET, neutrophil extracellular trap; Neutrophils; PMA, phorbol myristate acetate; PRM, parallel reaction monitoring; Renal sodium-glucose co-transporter-2; SGLT2, sodium-glucose co-transporter-2; TM, tamoxifen; fMLP, N-formyl-L-methionyl-L-leucyl-phenylalanine

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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Genet Metab Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália

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