Vaping and Lung Inflammation and Injury.
Annu Rev Physiol
; 84: 611-629, 2022 02 10.
Article
em En
| MEDLINE
| ID: mdl-34724436
ABSTRACT
The use of electronic (e)-cigarettes was initially considered a beneficial solution to conventional cigarette smoking cessation. However, paradoxically, e-cigarette use is rapidly growing among nonsmokers, including youth and young adults. In 2019, this rapid growth resulted in an epidemic of hospitalizations and deaths of e-cigarette users (vapers) due to acute lung injury; this novel disease was termed e-cigarette or vaping use-associated lung injury (EVALI). Pathophysiologic mechanisms of EVALI likely involve cytotoxicity and neutrophilic inflammation caused by inhaled chemicals, but further details remain unknown. The undiscovered mechanisms of EVALI are a barrier to identifying biomarkers and developing therapeutics. Furthermore, adverse effects of e-cigarette use have been linked to chronic lung diseases and systemic effects on multiple organs. In this comprehensive review, we discuss the diverse spectrum of vaping exposures, epidemiological and clinical reports, and experimental findings to provide a better understanding of EVALI and the adverse health effects of chronic e-cigarette exposure.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Pneumonia
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Lesão Pulmonar
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Sistemas Eletrônicos de Liberação de Nicotina
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Vaping
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Humans
Idioma:
En
Revista:
Annu Rev Physiol
Ano de publicação:
2022
Tipo de documento:
Article